How Super Vigra Works ?

Erection Physiology:

The physiological process of erection begins in the brain and involves the nervous and vascular systems. The chemicals that initiate erection are Neurotransmitters present in the brain. Any kind of stimulation Physical or psychological causes nerves to send messages to the vascular system, which results in significant blood flow to the penis. Two arteries in the penis supply blood to erectile tissue and the corpora cavernosa, which become engorged and expand as a result of increased blood flow and pressure.

Because blood must stay in the penis to maintain rigidity, Erectile tissue is enclosed by tunicae, which is fibrous elastic sheathes cinch which prevents blood from leaving the penis during erection. When muscles in the penis contract to stop the inflow of blood and open outflow channels, erection is reversed

Erection Chemistry

Part of the physiological process of erection involves the release of nitric oxide (NO) in vasculature of the corpus cavernosum as a result of sexual stimulation. During erection, nitric oxide is released from the axon terminals of the parasympathetic nerves and diffuses into smooth muscle cells of the arterial walls of the corpus cavernosum. The consequent activation of guanyl cyclase, converting guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP), causes smooth muscle relaxation, leading to dilation and increased influx of blood into the penile tissue. A commonly occurring enzyme in the penile tissues PDE5 or phosphodiesterase type 5 can degrade the cGMP which diminished the cGMP levels in the penile tissue causing the muscles to not relax and hence checks the flow of blood into the corpus cavernosum, leading to erection failure.

PDE5 inhibitors inhibit the degradation of cGMP by phosphodiesterase type 5 (PDE5), increasing blood flow to the penis during sexual stimulation. Icariin being a strong PDE5 inhibitor allows a healthy level of cGMP presence in the penile smooth muscles allowing and maintaining the erection


Like sildenafil (Viagra), Icariin, the active compound in SUPER VIGRA™, inhibits the activity of PDE-5. In vitro assays have demonstrated that icariin inhibits PDE-5 with an IC50 of around 1 micromolar, while sildenafil has an IC50 of about 6.7 nanomolar (.0066 micromolar)

Measured differently, the EC50 of Icariin is approximately 4.62 micromolar, while sildenafil's is .94 micromolar.

So in simpler language, 20mg of sildenafil can be said to be roughly equivalent to around 90mg of icariin.

A recently published Italian study modified icariin structurally and investigated a number of derivatives. Inhibitory concentrations for PDE-5 close to sildenafil could be reached. Moreover, the most potent PDE-5 inhibitor of this series was also found to be a less potent inhibitor of phosphodiesterase-6 (PDE-6) and cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE), thus showing it to have more specificity for PDE-5 than sildenafil* (the leading ED brand and biggest competitor to Viagra).

icariin has been shown to up-regulate genes associated with nitric oxide production and changes in adenosine/guanine monophosphate balance in ways that other PDE5 inhibitors do not.


* Wikipedia

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